{"id":551,"date":"2021-03-22T15:35:37","date_gmt":"2021-03-22T14:35:37","guid":{"rendered":"https:\/\/orientamento.dbcf.unisi.it\/?p=551"},"modified":"2021-03-22T16:10:34","modified_gmt":"2021-03-22T15:10:34","slug":"covalent-hyaluronic-based-coating-of-magnetite-nanoparticles-preparation-physicochemical-and-biological-characterization","status":"publish","type":"post","link":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/2021\/03\/22\/covalent-hyaluronic-based-coating-of-magnetite-nanoparticles-preparation-physicochemical-and-biological-characterization\/","title":{"rendered":"Covalent hyaluronic-based coating of magnetite nanoparticles: Preparation, physicochemical and biological characterization"},"content":{"rendered":"\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.msec.2019.110271\" target=\"_blank\" rel=\"noreferrer noopener\">Andrea Atrei, Claudia Innocenti, Stefania Lamponi, Serena Paesano, Gemma Leone, Annalisa Reale, Marco Paolino, Andrea Cappelli<\/a><\/p>\n\n\n\n<p id=\"publication-title\"><a href=\"https:\/\/doi.org\/10.1016\/j.msec.2019.110271\" target=\"_blank\" rel=\"noreferrer noopener\">Materials Science and Engineering: C Volume 107,&nbsp;February 2020, 110271<\/a><\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.msec.2019.110271\" target=\"_blank\" rel=\"noreferrer noopener\">In this paper we report about the preparation, physicochemical and biological characterization of a magneto responsive nanostructured material based on magnetite nanoparticles (NP) coated with hyaluronic acid (HA). A synthetic approach, based on a Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition \u201cclick\u201d reaction between azido-functionalized magnetite NP and a derivative of hyaluronic acid bearing propargylated ferulic acid groups (<strong>HA-FA-Pg<\/strong>), was developed to link covalently the polymer layer to the magnetite NP. The functionalization steps of the magnetite NP and their coating with the&nbsp;<strong>HA-FA-Pg<\/strong>&nbsp;layer were monitored by Fourier Transform Infrared (FTIR) spectroscopy and Thermal Gravimetric Analysis (TGA) while Dynamic Light Scattering (DLS) and \u03b6-potential measurements were performed to characterize the aqueous dispersions of the HA-coated magnetite NP. Aggregation and sedimentation processes were investigated also by UV-visible spectroscopy and the dispersions of HA-coated magnetite NP were found significantly more stable than those of bare NP. Magnetization and zero field cooled\/field cooled curves revealed that both bare and HA-coated magnetite NP are superparamagnetic at room temperature. Moreover, cytotoxicity studies showed that the coating with&nbsp;<strong>HA-FA-Pg<\/strong>&nbsp;significantly reduces the cytotoxicity of the magnetite NP providing the rational basis for the application of the HA-coated magnetite NP as healthcare material.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Andrea Atrei, Claudia Innocenti, Stefania Lamponi, Serena Paesano, Gemma Leone, Annalisa Reale, Marco Paolino, Andrea Cappelli Materials Science and Engineering: C Volume 107,&nbsp;February 2020, 110271 In this paper we report about the preparation, physicochemical and biological characterization of a magneto responsive nanostructured material based on magnetite nanoparticles (NP) coated with hyaluronic acid (HA). A synthetic&hellip; <a class=\"more-link\" href=\"https:\/\/orientamento.dbcf.unisi.it\/index.php\/2021\/03\/22\/covalent-hyaluronic-based-coating-of-magnetite-nanoparticles-preparation-physicochemical-and-biological-characterization\/\">Continua a leggere <span class=\"screen-reader-text\">Covalent hyaluronic-based coating of magnetite nanoparticles: Preparation, physicochemical and biological characterization<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":555,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[17],"tags":[],"class_list":["post-551","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-pubblicazioni","entry"],"jetpack_featured_media_url":"https:\/\/orientamento.dbcf.unisi.it\/wp-content\/uploads\/2021\/03\/1-s2.0-S092849311931817X-fx1_lrg.jpg","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/posts\/551","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/comments?post=551"}],"version-history":[{"count":3,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/posts\/551\/revisions"}],"predecessor-version":[{"id":558,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/posts\/551\/revisions\/558"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/media\/555"}],"wp:attachment":[{"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/media?parent=551"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/categories?post=551"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/orientamento.dbcf.unisi.it\/index.php\/wp-json\/wp\/v2\/tags?post=551"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}