S. Fusi, M. Frosini, M. Biagi, K. Zór, T. Rindzevicius, M. C. Baratto, L. De Vico, M. Corsini Polyhedron, Volume 187, 1 September 2020, 114650 Two new hydrophilic maltol derivatives were prepared with the aim of designing a chelator able to solubilize Fe(III) by complexation in physiologic condition. Sodium 2-((2-methyl-4-oxo-4H-pyran-3-yl)oxy)malonate (3) and lithium 2-((3-hydroxy-4-oxo-4H-pyran-2-yl)methyl)malonate (7) were…
Categoria: Pubblicazioni
Modern quantum chemistry with [Open]Molcas
Francesco Aquilante, Jochen Autschbach, Alberto Baiardi, Stefano Battaglia, Veniamin A. Borin, Liviu F. Chibotaru, Irene Conti, Luca De Vico, Mickaël Delcey, Ignacio Fdez. Galván, Nicolas Ferré, Leon Freitag, Marco Garavelli, Xuejun Gong, Stefan Knecht, Ernst D. Larsson, Roland Lindh, Marcus Lundberg, Per Åke Malmqvist, Artur Nenov, Jesper Norell, Michael Odelius, Massimo Olivucci, Thomas B. Pedersen, Laura Pedraza-González, Quan M. Phung, Kristine Pierloot, Markus Reiher, Igor Schapiro, Javier Segarra-Martí, Francesco Segatta, Luis Seijo, Saumik Sen, Dumitru-Claudiu Sergentu, Christopher J. Stein, Liviu Ungur, Morgane Vacher, Alessio Valentini, and Valera Veryazov J. Chem. Phys. 152, 214117 (2020)…
Covalent hyaluronic-based coating of magnetite nanoparticles: Preparation, physicochemical and biological characterization
Andrea Atrei, Claudia Innocenti, Stefania Lamponi, Serena Paesano, Gemma Leone, Annalisa Reale, Marco Paolino, Andrea Cappelli Materials Science and Engineering: C Volume 107, February 2020, 110271 In this paper we report about the preparation, physicochemical and biological characterization of a magneto responsive nanostructured material based on magnetite nanoparticles (NP) coated with hyaluronic acid (HA). A synthetic…
High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor
G. Landi, P. Linciano, G. Tassone, M. P. Costi, S. Mangani and C. Pozzi Acta Cryst. (2020). D76, 558-564 The protozoan parasite Trypanosoma brucei is the etiological agent of human African trypanosomiasis (HAT). HAT, together with other neglected tropical diseases, causes serious health and economic issues, especially in tropical and subtropical areas. The classical antifolates targeting dihydrofolate reductase (DHFR) are ineffective towards trypanosomatid parasites owing to…